#BECA #PhD position Interplay between #galectins and #glycosphingolipids

Starting date: As soon as possible

Duration: 36 months

Salary: According to Institut Curie rules: around 31,000 Euros/year

Short description: PhD project in cell biology and animal physiology between research units at Institut Curie, Institut Jacques Monod and IBYME, CONICET. Based on our earlier contributions in the fields of endocytosis, intracellular trafficking, and mouse genetics, the project aims at dissecting the functions of galectins in vivo in these processes. Previously established mouse models are used in which galectins are genetically inactivated alone or in combination, and in which glycosphingolipid expression is prevented in a tissue specific manner. The project involves intravital imaging in addition to light and electron microscopy techniques, cellular biochemistry, histology and experimental models in vivo.

Key publications:

Renard et al., 2015. Endophilin-A2 functions in membrane scission in clathrin-independent endocytosis. Nature. 517:493-496

Lakshminarayan et al., 2014. Galectin-3 drives glycosphingolipid-dependent biogenesis of clathrin-independent carriers. Nature Cell Biol. 16:595-606.

Croci et al, 2014. Glycosylation-dependent lectin-receptor interactions preserve angiogenesis in anti-VEGF refractory tumors. Cell. 156:744-758.

Ilarregui et al, 2009. Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10. Nature Immunol. 10:981-991.

Gendronneau G, Sanii S, et al., 2015. Overexpression of galectin-7 in mouse epidermis leads to loss of cell junctions and defective skin repair. PLos One Mar 5;10(3):e0119031.

Requirements: Ideal candidates are expected to hold degrees in a relevant scientific field, have a strong interest in cell biology and mouse physiology, excellent command of English, and the ability to work

as members of an international group. Experience in imaging techniques will be considered an advantage. While being primarily positioned in Paris, the successful candidate is expected to show mobility between France and Argentina for long-term training and research stays.

Host Institutes: Institut Curie

Chemical Biology of Membranes and Therapeutic Delivery unit

U1143 INSERM — UMR3666 CNRS

26 rue d'Ulm

75248 Paris Cedex 05

France

Institut Jacques Monod

Morphogenesis, homeostasis and pathologies

UMR 7592 CNRS - Université Paris Diderot

15 rue Hélène Brion

75205 Paris Cedex 13

France

Supervisors: Ludger Johannes (ludger.johannes@curie.fr, +33 1-56246351, https://chemicalbiology.curie.fr/en)

Gabriel Rabinovich (gabriel.r@ibyme.conicet.gov.ar; +54-11-4783-2869; ext 266) (http://www.ibyme.org.ar)

Mireille Viguier (mireille.viguier@univ-paris-diderot.fr, +33 1-57278107, http://www.ijm.fr/recherche/equipes/morphogenese-homeostasie/)

How to apply: Send the following documents via e-mail to Dr. Pablo Hockl (pablo.hockl@gmail.com):

• Letter of motivation (research interests, reasons for applying to this project)

• A complete CV (including publications, conferences, international training, etc.)

• Two letters of recommendation, or complete contact information for 2 references

Deadline

for application: Applications can be submitted at any time until August 30

For further

information: Please contact the supervisors of this project